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Preferred Name |
Alpha-tocopherol
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Definition |
The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body.
CRCH Definition: Tocopherol with three methyl groups on its chromanol ring.
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Synonyms & Abbreviations |
α-tocopherol;
ALPHA.-TOCOPHEROL
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
Alpha-tocopherol
Alpha-Tocopherol
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ReferenceCode |
NCI Thesaurus Code:C74960
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ReferenceURL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C74960
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Influence type |
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Subgroups and cutoffs |
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Have |
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PMID |
17943452
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