Prostate Cancer Ontology
Center for Systems Biology, Sichuan University West China Hospital, Sichuan China
XRCC3
Preferred Name XRCC3 X-ray repair cross complementing 3
Definition This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Synonyms & Abbreviations CMM6
ReferenceCode Location: 14q32.33; Sequence: Chromosome: 14; NC_000014.9 (103697611..103715486, complement)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/7517/
PMID NA
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