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Definition |
Cardiovascular mortality is now the most common cause of death in PCa patients, even exceeding PCa mortality. Several studies showed that ADT, even after only 6 months, was associated with an increased risk of diabetes mellitus, cardiovascular disease, and myocardial infarction. The RTOG 92-02 and 94-08 confirmed an increased cardiovascular risk, unrelated to the duration of ADT and not accompanied by an overall increased cardiovascular mortality. No increase in cardiovascular mortality has been reported in a systematic meta-analysis of trials RTOG 8531, 8610, 9202, EORTC 30891 or EORTC 22863. However,an increase in cardiovascular mortality has been reported in patients suffering from previous congestiveheart failure or myocardial infarction in a retrospective database analysis or presenting with a metabolic syndrome.
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