Prostate Cancer Ontology
Center for Systems Biology, Soochow University, Suzhou China
PPM1D
Preferred Name PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D
Definition The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
Synonyms & Abbreviations WIP1; IDDGIP; PP2C-DELTA
ReferenceCode Location: 17q23.2; Sequence: Chromosome: 17; NC_000017.11 (60600183..60666280)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/8493/
PMID NA
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