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Definition |
The high number of random and systematic errors associated with TRUS-guided random biopsy regimens means that this procedure is not sufficiently accurate for selecting candidates for focal therapy. Perineal biopsy or magnetic resonance imaging (MRI) may be useful tools. For characterizing men considering focal therapy, transperineal prostate biopsy using a template-guided approach is recommended. When used with a 5 mm sampling frame, this approach can rule in or out PCa foci with volumes of 0.5 mL and 0.2 mL with 90% certainty. Thus, the exact anatomical localization of the index lesion - defined as the biologically most aggressive - can be accurately determined.
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