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Preferred Name |
Abiraterone Acetate
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Definition |
An orally active acetate sester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels./NCI-GLOSS Definition: A substance being studied in the treatment of prostate cancer and breast cancer. It blocks tissues from making androgens (male hormones), such as testosterone. This may cause the death of cancer cells that need androgens to grow. It is a type of anti-androgen.
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Synonyms & Abbreviations |
17-(3-Pyridyl)-5,16-androstadien-3beta-acetate
Abiraterone Acetate
ABIRATERONE ACETATE
abiraterone acetate
Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3beta)-/CB7630/Zytiga
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ReferenceCode |
NCI Thesaurus Code:C68845
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ReferenceURL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C68845
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PMID |
NA
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