Prostate Cancer Ontology
Center for Systems Biology, Soochow University, Suzhou China
MXI1
Preferred Name MXI1 MAX interactor 1, dimerization protein
Definition Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Synonyms & Abbreviations MXI; MAD2; MXD2; bHLHc11
ReferenceCode Location: 10q25.2; Sequence: Chromosome: 10; NC_000010.11 (110207605..110287365)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/4601/
PMID NA
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