Prostate Cancer Ontology
Center for Systems Biology, Sichuan University West China Hospital, Sichuan China
跳过导航链接。
折叠 Prostate cancerProstate cancer
展开 Epidemiological aspects of prostate cancerEpidemiological aspects of prostate cancer
展开 Diagnostic aspects of prostate cancerDiagnostic aspects of prostate cancer
折叠 Therapeutic aspects of prostate cancerTherapeutic aspects of prostate cancer
展开 Deferred treatmentDeferred treatment
展开 SurgerySurgery
展开 RadiotherapyRadiotherapy
展开 CryotherapyCryotherapy
展开 Hormonal therapyHormonal therapy
折叠 ChemotherapyChemotherapy
展开 Castration-resistant prostate cancer (CRPC)Castration-resistant prostate cancer (CRPC)
展开 Metastatic prostate cancerMetastatic prostate cancer
展开 Other treatmentOther treatment
Estramustine
Preferred Name Estramustine
Definition A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)/NCI-GLOSS Definition: A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.
Synonyms & Abbreviations 17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate))
estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate]
Estradiol 3-[bis(2-chloroethyl)carbamate]
estradiol 3-bis(2-chloroethyl)carbamate
estramustine
ESTRAMUSTINE
Estramustine
Leo 275
RO 21-8837
ReferenceCode NCI Thesaurus Code:C479
ReferenceURL https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C479
PMID NA
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