Prostate Cancer Ontology
Center for Systems Biology, Sichuan University West China Hospital, Sichuan China

雌二醇氮芥

Preferred Name	Estramustine
Definition	A synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. (NCI04)/NCI-GLOSS Definition: A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.
Synonyms & Abbreviations	17beta-(estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate)) estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate] Estradiol 3-[bis(2-chloroethyl)carbamate] estradiol 3-bis(2-chloroethyl)carbamate estramustine ESTRAMUSTINE Estramustine Leo 275 RO 21-8837
ReferenceCode	NCI Thesaurus Code:C479
ReferenceURL	https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C479
PMID	NA