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Definition |
Two strategies have been attempted to neutralise oestrogen cardiotoxicity. Parenteral oestrogen (polyoestradiol phosphate) to avoid first-pass hepatic metabolism was as effective as CAB for survival, but with still more non-fatal cardiovascular events. The use of either warfarin sodium, 1 mg/day, or aspirin, 75-100 mg/day in combination with DES,1 mg/day or 3 mg/day, did not suppress the thromboembolic complications associated with DES. These results precluded oestrogen as a standard first-line treatment.
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