Definition |
Early studies by the Veterans Administration (VACURG) tested oral Diesthylstilboesterol (DES) at 5 mg/day. This dosage was associated with high cardiovascular morbidity and mortality, which was secondary to first-pass hepatic metabolism and the formation of thrombogenic metabolites. Lower doses of 1 mg/day and 3 mg/day were found to be as effective as bilateral orchiectomy, with still more side effects compared to castration.
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