Prostate Cancer Ontology
Center for Systems Biology, Sichuan University West China Hospital, Sichuan China

Cyproterone acetate (CPA)

Preferred Name	Cyproterone Acetate
Definition	The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels./NCI-GLOSS Definition: A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery.
Synonyms & Abbreviations	3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(Acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)- 6-Chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetate Andro-Diane Androcur Chloro-6-hydroxy-17 Alpha Methylene-1 Alpha, 2 Alpha Pregnadiene-4,6 Dione-3, 20 Acetate CyPat Cyprone Cyprostat Cyproteronazetat Cyproterone Acetate cyproterone acetate CYPROTERONE ACETATE Cyproteroni Acetas Diane Dianette SH 714 SH-714
ReferenceCode	NCI Thesaurus Code:C1059
ReferenceURL	https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1059
PMID	NA