Preferred Name	Flutamide
Definition	A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)/NCI-GLOSS Definition: An anticancer drug that is a type of antiandrogen.
Synonyms & Abbreviations	2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide 4'-Nitro-3'-trifluoromethylisobutyranilide Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide Apimid Cebatrol Chimax Cytomid Drogenil Euflex Eulexin Eulexine Flucinom Flucinome Flugerel Fluken Flulem FLUT Fluta-Gry Flutabene Flutacan Flutamex Flutamide flutamide FLUTAMIDE Flutamin Flutan Flutaplex Fugerel Grisetin Niftolide Oncosal Profamid Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)- Prostacur Prostadirex Prostica Prostogenat Sch 13521 SCH 13521 Tafenil Tecnoflut Testotard
ReferenceCode	NCI Thesaurus Code:C509
ReferenceURL	https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C509
PMID	NA