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Definition |
Non-steroidal anti-androgens monotherapy have been promoted on the basis of improved quality of life (QoL) and compliance compared to castration. They do not suppress testosterone secretion and it is claimed that libido, overall physical performance and bone mineral density (BMD) are preserved. Non-androgen pharmacological side-effects differ, with bicalutamide showing a more favourable safety and tolerability profile than nilutamide and flutamide. All three agents share a common liver toxicity (occasionally fatal) and liver enzymes must be monitored regularly.
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