Definition |
These oral compounds are classified according to their chemical structure as: • steroidal, e.g. cyproterone acetate (CPA), megestrol acetate and medroxyprogesterone acetate; • non-steroidal or pure, e.g. nilutamide, flutamide and bicalutamide.Both classes compete with androgens at the receptor level. This is the sole action of non-steroidal antiandrogens that leads to an unchanged or slightly elevated testosterone level. Conversely, steroidal antiandrogens have progestational properties leading to a central inhibition by crossing the blood-brain barrier
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