Prostate Cancer Ontology
Center for Systems Biology, Soochow University, Suzhou China
EPHB2
Preferred Name EPHB2 EPH receptor B2
Definition This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Synonyms & Abbreviations DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5
ReferenceCode Location: 1p36.12; Sequence: Chromosome: 1; NC_000001.11 (22710770..22921500)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/2048/
PMID NA
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