Prostate Cancer Ontology
Center for Systems Biology, Soochow University, Suzhou China
ELAC2
Preferred Name ELAC2 elaC ribonuclease Z 2
Definition The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Synonyms & Abbreviations ELC2; HPC2; COXPD17
ReferenceCode Location: 17p12; Sequence: Chromosome: 17; NC_000017.11 (12991612..13018064, complement)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/60528/
PMID NA
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