Prostate Cancer Ontology
Center for Systems Biology, Sichuan University West China Hospital, Sichuan China
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折叠 Prostate cancerProstate cancer
折叠 Epidemiological aspects of prostate cancerEpidemiological aspects of prostate cancer
展开 Basic information of patientBasic information of patient
展开 Personal medical historyPersonal medical history
折叠 Genetic and epigenetic of prostate cancerGenetic and epigenetic of prostate cancer
展开 Lifestyles of prostate cancerLifestyles of prostate cancer
展开 Diagnostic aspects of prostate cancerDiagnostic aspects of prostate cancer
展开 Therapeutic aspects of prostate cancerTherapeutic aspects of prostate cancer
ELAC2
Preferred Name ELAC2 elaC ribonuclease Z 2
Definition The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Synonyms & Abbreviations ELC2; HPC2; COXPD17
ReferenceCode Location: 17p12; Sequence: Chromosome: 17; NC_000017.11 (12991612..13018064, complement)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/60528/
PMID NA
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