Prostate Cancer Ontology
Center for Systems Biology, Soochow University, Suzhou China
CD82
Preferred Name CD82 CD82 molecule
Definition This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms & Abbreviations R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27
ReferenceCode Location: 11p11.2; Sequence: Chromosome: 11; NC_000011.10 (44565591..44620363)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/3732/
PMID NA
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