Prostate Cancer Ontology
Center for Systems Biology, Sichuan University West China Hospital, Sichuan China
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折叠 Prostate cancerProstate cancer
折叠 Epidemiological aspects of prostate cancerEpidemiological aspects of prostate cancer
展开 Basic information of patientBasic information of patient
展开 Personal medical historyPersonal medical history
折叠 Genetic and epigenetic of prostate cancerGenetic and epigenetic of prostate cancer
展开 Lifestyles of prostate cancerLifestyles of prostate cancer
展开 Diagnostic aspects of prostate cancerDiagnostic aspects of prostate cancer
展开 Therapeutic aspects of prostate cancerTherapeutic aspects of prostate cancer
CASP8
Preferred Name CASP8 caspase 8
Definition This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Synonyms & Abbreviations CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
ReferenceCode Location: 2q33.1; Sequence: Chromosome: 2; NC_000002.12 (201233443..201287711)
ReferenceURL https://www.ncbi.nlm.nih.gov/gtr/genes/841/
PMID NA
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