Preferred Name	HMG-CoA Reductase Inhibitor
Definition	Any substance that inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. Inhibition of HMG-CoA reductase acts to lower plasma cholesterol and lipoprotein levels. NCI-GLOSS Definition: Any of a group of drugs that lower the amount of cholesterol and certain fats in the blood. Statins inhibit a key enzyme that helps make cholesterol. Statin drugs are being studied in the prevention and treatment of cancer.
Synonyms & Abbreviations	HMG-CoA reductase inhibitor HMG-CoA Reductase Inhibitor Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors hydroxymethylglutaryl-coenzyme A reductase inhibitor statin Statin
ReferenceCode	NCI Thesaurus Code:C1655
ReferenceURL	https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1655
PMID	NA